Responsable : Fabrice FLEURY

Projets et objectifs: L’objectif de notre équipe est de comprendre les mécanismes moléculaires et biochimiques de la réparation de l’ADN, notamment par recombinaison homologue (RH), et d’explorer certaines voies de réparation impliquées dans les processus de résistance aux traitements anticancéreux.
Nous étudions en particulier Rad51, protéine clef de la RH fréquemment surexprimée dans les cellules cancéreuses et qui est à l’origine de résistance aux radio- et chimio-thérapies anticancéreuses.
Les interactions impliquant des protéines de réparation de l’ADN sont étudiées par criblage à haut débit (Puces à protéines). Leur caractérisation et leur analyse structure-fonction sont abordées par un ensemble d’outils biophysiques (disponibles via la plate-forme IMPACT) parfaitement maîtrisés par notre équipe. Les informations moléculaires ainsi extraites sont ensuite exploitées pour mieux comprendre les régulations au niveau cellulaire. Cette interface moléculaire-cellulaire est l’un des points forts qui caractérise notre équipe.

Mots-clés : , , ,

Membres

Anciens membres de l'équipe


Projets

Publications

3 publications

Velic, Denis; Demeyer, Alexandre; Peterlini, Thibaut; Benhelli-Mokrani, Houda; Mathé-Allainmat, Monique; Masson, Jean-Yves; Fleury, Fabrice

Molecular Determinant of DIDS Analogs Targeting RAD51 Activity Article de journal

Dans: Molecules, 26 (18), p. 5460, 2021, ISSN: 1420-3049.

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Demeyer, A.; Benhelli-Mokrani, H.; Chénais, B.; Weigel, P.; Fleury, F.

Inhibiting homologous recombination by targeting RAD51 protein Article de journal

Dans: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 1876 (2), p. 188597, 2021, ISSN: 0304419X.

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Le, Van-Tuyen; Bertrand, Samuel; du Pont, Thibaut Robiou; Fleury, Fabrice; Caroff, Nathalie; Bourgeade-Delmas, Sandra; Gentil, Emmanuel; Logé, Cedric; Genta-Jouve, Gregory; Grovel, Olivier

Untargeted Metabolomics Approach for the Discovery of Environment-Related Pyran-2-Ones Chemodiversity in a Marine-Sourced Penicillium restrictum Article de journal

Dans: Marine Drugs, 19 (7), p. 378, 2021, ISSN: 1660-3397.

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10 publications

Chabot, Thomas; Cheraud, Yvonnick; Fleury, Fabrice

Relationships between DNA repair and RTK-mediated signaling pathways Article de journal

Dans: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, p. 188495, 2020, ISSN: 0304419X.

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Méresse, Sarah; Fodil, Mostefa; Fleury, Fabrice; Chénais, Benoît

Fucoxanthin, a Marine-Derived Carotenoid from Brown Seaweeds and Microalgae: A Promising Bioactive Compound for Cancer Therapy Article de journal

Dans: International Journal of Molecular Sciences, 21 (23), p. 9273, 2020, ISSN: 1422-0067.

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Chabot, Thomas

Modulation de l'activité du Rad51 par le récepteur tyrosine kinase c-Met dans la réparation des cassures double-brin de l'ADN Thèse

Université de Nantes, 2020, (294 pages).

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Fleury, Fabrice; Demeyer, Alexandre; Weigel, Pierre; Chenais, Benoit; Mathé, Monique; Lebreton, Jacques

Disulfonate stilbenes for use in the treatment of proliferative diseases Patent

WO2020104634A1, 2020.

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Ayadi, Nizar; Lafont, Florian; Charlier, Cathy; Benhelli-Mokrani, Houda; Sokolov, Pavel; Sukhanova, Alyona; Fleury, Fabrice; Nabiev, Igor

Comparative Advantages and Limitations of Quantum Dots in Protein Array Applications Chapitre d'ouvrage

Dans: Quantum Dots, 2135 , p. 259–273, Springer, New York, NY, Humana, 2020.

BibTeX

Yaremenko, Ivan A; Coghi, Paolo; Prommana, Parichat; Qiu, Congling; Radulov, Peter S; Qu, Yuanqing; Belyakova, Yulia Yu; Zanforlin, Enrico; Kokorekin, Vladimir A; Wu, Yuki Yu Jun; Fleury, Fabrice; Uthaipibull, Chairat; Wong, Vincent Kam Wai; Terent'ev, Alexander O

Synthetic Peroxides Promote Apoptosis of Cancer Cells by Inhibiting P-Glycoprotein ABCB5 Article de journal

Dans: ChemMedChem, 15 (13), p. 1118–1127, 2020, ISSN: 18607187.

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Aganyants, Hovsep; Weigel, Pierre; Hovhannisyan, Yeranuhi; Lecocq, Michèle; Koloyan, Haykanush; Hambardzumyan, Artur; Hovsepyan, Anichka; Hallet, Jean Noël; Sakanyan, Vehary

Rational engineering of the substrate specificity of a thermostable d-hydantoinase (Dihydropyrimidinase) Article de journal

Dans: High-Throughput, 9 (1), 2020, ISSN: 25715135.

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Yaremenko, Ivan A; Radulov, Peter S; Belyakova, Yulia Yu; Demina, Arina A; Fomenkov, Dmitriy I; Barsukov, Denis V; Subbotina, Irina R; Fleury, Fabrice; Terent'ev, Alexander O

Catalyst Development for the Synthesis of Ozonides and Tetraoxanes Under Heterogeneous Conditions: Disclosure of an Unprecedented Class of Fungicides for Agricultural Application Article de journal

Dans: Chemistry - A European Journal, 26 (21), p. 4734–4751, 2020, ISSN: 15213765.

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Lafont, Florian; Fleury, Fabrice; Benhelli-Mokrani, Houda

DNA-PKcs Ser2056 auto-phosphorylation is affected by an O-GlcNAcylation/phosphorylation interplay Article de journal

Dans: Biochimica et Biophysica Acta (BBA) - General Subjects, 1864 (12), p. 129705, 2020, ISSN: 0304-4165.

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Vil', Vera A; Yaremenko, Ivan A; Fomenkov, Dmitri I; Levitsky, Dmitri O; Fleury, Fabrice; Terent'ev, Alexander O

Ion exchange resin-catalyzed synthesis of bridged tetraoxanes possessing in vitro cytotoxicity against HeLa cancer cells Article de journal

Dans: Chemistry of Heterocyclic Compounds, 56 (6), p. 722–726, 2020, ISSN: 1573-8353.

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2 publications

Velic, Denis; Charlier, Cathy; Popova, Milena; Jaunet-Lahary, Titouan; Bouchouireb, Zakaria; Henry, Sébastien; Weigel, Pierre; Masson, Jean-Yves; Laurent, Adèle D; Nabiev, Igor; Fleury, Fabrice

Interactions of the Rad51 inhibitor DIDS with human and bovine serum albumins: Optical spectroscopy and isothermal calorimetry approaches Article de journal

Dans: Biochimie, 167 , p. 187–197, 2019, ISSN: 0300-9084.

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Chabot, Thomas; Defontaine, Alain; Marquis, Damien; Renodon-Corniere, Axelle; Courtois, Emmanuelle; Fleury, Fabrice; Cheraud, Yvonnick

New phosphorylation sites of rad51 by c-met modulates presynaptic filament stability Article de journal

Dans: Cancers, 11 (3), 2019, ISSN: 20726694.

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4 publications

Benhelli-Mokrani, Houda; Mansuroglu, Zeyni; Chauderlier, Alban; Albaud, Benoit; Gentien, David; Sommer, Sabrina; Schirmer, Claire; Laqueuvre, Lucie; Josse, Thibaut; Buée, Luc; Lefebvre, Bruno; Galas, Marie Christine; Souès, Sylvie; Bonnefoy, Eliette

Genome-wide identification of genic and intergenic neuronal DNA regions bound by Tau protein under physiological and stress conditions Article de journal

Dans: Nucleic acids research, 46 (21), p. 11405–11422, 2018, ISSN: 13624962.

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Deriabin, Konstantin V; Yaremenko, Ivan A; Chislov, Mikhail V; Fleury, Fabrice; Terent'Ev, Alexander O; Islamova, Regina M

Similar nature leads to improved properties: Cyclic organosilicon triperoxides as promising curing agents for liquid polysiloxanes Article de journal

Dans: New Journal of Chemistry, 42 (18), p. 15006–15013, 2018, ISSN: 13699261.

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Lafont, Florian; Ayadi, Nizar; Charlier, Cathy; Weigel, Pierre; Nabiev, Igor; Benhelli-Mokrani, Houda; Fleury, Fabrice

Assessment of DNA-PKcs kinase activity by quantum dot–based microarray Article de journal

Dans: Scientific Reports, 8 (1), p. 1–12, 2018, ISSN: 20452322.

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Jaunet-Lahary, Titouan; Vercauteren, Daniel P; Fleury, Fabrice; Laurent, Adèle D

Computational simulations determining disulfonic stilbene derivative bioavailability within human serum albumin Article de journal

Dans: Physical Chemistry Chemical Physics, 20 (26), p. 18020–18030, 2018, ISSN: 14639076.

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5 publications

Bosseboeuf, Adrien; Feron, Delphine; Tallet, Anne; Rossi, Cédric; Charlier, Cathy; Garderet, Laurent; Caillot, Denis; Moreau, Philippe; Cardó-Vila, Marina; Pasqualini, Renata; Arap, Wadih; Nelson, Alfreda Destea; Wilson, Bridget S; Perreault, Hélène; Piver, Eric; Weigel, Pierre; Girodon, François; Harb, Jean; Bigot-Corbel, Edith; Hermouet, Sylvie

Monoclonal IgG in MGUS and multiple myeloma targets infectious pathogens Article de journal

Dans: JCI Insight, 2 (19), p. 1–18, 2017, ISSN: 0021-9738.

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Yaremenko, Ivan A; Syroeshkin, Mikhail A; Levitsky, Dmitri O; Fleury, Fabrice; Terent'ev, Alexander O

Cyclic peroxides as promising anticancer agents: in vitro cytotoxicity study of synthetic ozonides and tetraoxanes on human prostate cancer cell lines Article de journal

Dans: Medicinal Chemistry Research, 26 (1), p. 170–179, 2017, ISSN: 1554-8120.

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Levitsky, Dmitri O; Gloriozova, Tatyana A; Poroikov, Vladimir V; Valery, M

ANABOLIC CYANOSTEROIDS AND THEIR BIOLOGICAL ACTIVITIES – A BRIEF REVIEW Article de journal

Dans: 6 (12), p. 127–151, 2017, ISBN: 2017121061.

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Faucon, Adrien; Benhelli-Mokrani, Houda; Fleury, Fabrice; Dutertre, Stéphanie; Tramier, Marc; Boucard, Joanna; Lartigue, Lénaïc; Nedellec, Steven; Hulin, Philippe; Ishow, Eléna

Bioconjugated fluorescent organic nanoparticles targeting EGFR-overexpressing cancer cells Article de journal

Dans: Nanoscale, 9 (45), p. 18094–18106, 2017, ISSN: 20403372.

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Alligand, Brendan; Breton, Magali Le; Marquis, Damien; Vallette, François; Fleury, Fabrice

Functional effects of diphosphomimetic mutations at cAbl-mediated phosphorylation sites on Rad51 recombinase activity Article de journal

Dans: Biochimie, 139 , p. 115–124, 2017, ISSN: 61831638.

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9 publications

Silva, Viviane A O; Lafont, Florian; Benhelli-Mokrani, Houda; Breton, Magali Le; Hulin, Philippe; Chabot, Thomas; Paris, François; Sakanyan, Vehary; Fleury, Fabrice

Rapid diminution in the level and activity of DNA-dependent protein kinase in cancer cells by a reactive nitro-benzoxadiazole compound Article de journal

Dans: International Journal of Molecular Sciences, 17 (5), 2016, ISSN: 14220067.

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Krylov, Igor B; Kompanets, Mykhailo O; Novikova, Katerina V; Opeida, Iosip O; Kushch, Olga V; Shelimov, Boris N; Nikishin, Gennady I; Levitsky, Dmitri O; Terent'ev, Alexander O

Well-Known Mediators of Selective Oxidation with Unknown Electronic Structure: Metal-Free Generation and EPR Study of Imide-N-oxyl Radicals Article de journal

Dans: Journal of Physical Chemistry A, 120 (1), p. 68–73, 2016, ISSN: 15205215.

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Mansuroglu, Zeyni; Benhelli-Mokrani, Houda; Marcato, Vasco; Sultan, Audrey; Violet, Marie; Chauderlier, Alban; Delattre, Lucie; Loyens, Anne; Talahari, Smail; Bégard, Séverine; Nesslany, Fabrice; Colin, Morvane; Souès, Sylvie; Lefebvre, Bruno; Buée, Luc; Galas, Marie Christine; Bonnefoy, Eliette

Loss of Tau protein affects the structure, transcription and repair of neuronal pericentromeric heterochromatin Article de journal

Dans: Scientific Reports, 6 (September), p. 1–16, 2016, ISSN: 20452322.

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Jaunet-Lahary, Titouan; Goupille, Anaïs; Jacquemin, Denis; Fleury, Fabrice; Graton, Jérôme; Laurent, Adèle D

A Joint Theoretical and Experimental Study of the Behavior of the DIDS Inhibitor and its Derivatives Article de journal

Dans: ChemPhysChem, 3 , p. 2434–2445, 2016, ISSN: 14397641.

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Terent'Ev, Alexander O; Pastukhova, Zhanna Yu; Yaremenko, Ivan A; Novikov, Roman A; Demchuk, Dmitry V; Bruk, Lev G; Levitsky, Dmitri O; Fleury, Fabrice; Nikishin, Gennady I

Selective transformation of tricyclic peroxides with pronounced antischistosomal activity into 2-hydroxy-1,5-diketones using iron (II) salts Article de journal

Dans: Tetrahedron, 72 (24), p. 3421–3426, 2016, ISSN: 14645416.

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Levitsky, Dmitri O; Gloriozova, Tatyana A; Poroikov, Vladimir V; Dembitsky, Valery M

Mathews Journal of Pharmaceutical Science Naturally Occurring Isocyano / Isothiocyanato Compounds : Their Pharmacological and SAR Activities Article de journal

Dans: MATHEWS, Open Access Journals, 1 (1), p. 1–15, 2016.

BibTeX

Zdvizhkov, Alexander T; Terent'Ev, Alexander O; Radulov, Peter S; Novikov, Roman A; Tafeenko, Viktor A; Chernyshev, Vladimir V; Ilovaisky, Alexey I; Levitsky, Dmitri O; Fleury, Fabrice; Nikishin, Gennady I

Transformation of 2-allyl-1,3-diketones to bicyclic compounds containing 1,2-dioxolane and tetrahydrofuran rings using the I2/H2O2 system Article de journal

Dans: Tetrahedron Letters, 57 (8), p. 949–952, 2016, ISSN: 18733581.

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Sakanyan, Vehary; Hulin, Philippe; Sousa, Rodolphe Alves De; Silva, Viviane A O; Hambardzumyan, Artur; Nedellec, Steven; Tomasoni, Christophe; Logé, Cédric; Pineau, Charles; Roussakis, Christos; Fleury, Fabrice; Artaud, Isabelle

Activation of EGFR by small compounds through coupling the generation of hydrogen peroxide to stable dimerization of Cu/Zn SOD1 Article de journal

Dans: Scientific Reports, 6 (January), p. 1–14, 2016, ISSN: 20452322.

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Faucon, Adrien; Benhelli-Mokrani, Houda; Fleury, Fabrice; Dubreil, Laurence; Hulin, Philippe; Nedellec, Steven; Doussineau, Tristan; Antoine, Rodolphe; Orlando, Tomas; Lascialfari, Alessandro; Fresnais, Jérôme; Lartigue, Lénaïc; Ishow, Eléna

Tuning the architectural integrity of high-performance magneto-fluorescent core-shell nanoassemblies in cancer cells Article de journal

Dans: Journal of Colloid and Interface Science, 479 , p. 139–149, 2016, ISSN: 10957103.

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5 publications

Alligand, Brendan

Étude du rôle des phosphorylations de Rad51 en Y54 et en Y315 sur son fonctionnement Thèse

Université de Nantes, 2015.

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Faucon, Adrien; Benhelli-Mokrani, Houda; w Córdova, Luis A; Brulin, Bénédicte; Heymann, Dominique; Hulin, Philippe; Nedellec, Steven; Ishow, Eléna

Are Fluorescent Organic Nanoparticles Relevant Tools for Tracking Cancer Cells or Macrophages? Article de journal

Dans: Advanced Healthcare Materials, 4 (17), p. 2727–2734, 2015, ISSN: 21922659.

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Qi, Haoling; Cantrelle, François Xavier; Benhelli-Mokrani, Houda; Smet-Nocca, Caroline; Buée, Luc; Lippens, Guy; Bonnefoy, Eliette; Galas, Marie Christine; Landrieu, Isabelle

Nuclear magnetic resonance spectroscopy characterization of interaction of Tau with DNA and its regulation by phosphorylation Article de journal

Dans: Biochemistry, 54 (7), p. 1525–1533, 2015, ISSN: 15204995.

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Velic, Denis; Couturier, Anthony M; Ferreira, Maria Tedim; Rodrigue, Amélie; Poirier, Guy G; Fleury, Fabrice; Masson, Jean-Yves

DNA Damage Signalling and Repair Inhibitors: The Long-Sought-After Achilles’ Heel of Cancer Article de journal

Dans: Biomolecules, 5 (4), p. 3204–3259, 2015, ISSN: 2218-273X.

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Terent'ev, Alexander O; Zdvizhkov, Alexander T; Levitsky, Dmitri O; Fleury, Fabrice; Pototskiy, Roman A; Kulakova, Alena N; Nikishin, Gennady I

Organocatalytic peroxidation of malonates, β-ketoesters, and cyanoacetic esters using n-Bu4NI/t-BuOOH-mediated intermolecular oxidative C(sp3)-O coupling Article de journal

Dans: Tetrahedron, 71 (47), p. 8985–8990, 2015, ISSN: 14645416.

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