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Publications de l’équipe Mécanisme et régulation de la réparation de l’ADN


Vil’ VA., Yaremenko IA., Fomenkov DI., Levitsky DO., Fleury F., Terent’ev AO. Ion exchange resin-catalyzed synthesis of bridged tetraoxanes possessing in vitro cytotoxicity against HeLa cancer cells. Chemistry of Heterocyclic Compounds, 2020, 56(6), 722–726.

Yaremenko IA., Coghi P., Prommana P., Qiu C., Radulov PS., Qu Y., Belyakova YY., Zanforlin E., Kokorekin VA, Wu YYJ., Fleury F., Wong VKW., Uthaipibull C., Terent’ev A. Synthetic peroxides promote apoptosis of cancer cells inhibiting of P-glycoprotein ABCB5. ChemMedChem, 2020, Mar 10. doi : 10.1002/cmdc.202000042.

Ayadi N., Lafont F., Charlier C., Benhelli-Mokrani H., Sokolov P., Sukhanova A., Fleury F., Nabiev I. Comparative Advantages and Limitations of Quantum Dots in Protein Array Applications. Methods Mol Biol, 2020, 2135:259-273. doi : 10.1007/978-1-0716-0463-2_16.

Aganyants H., Weigel P., Hovhannisyan Y., Lecocq M., Koloyan H., Hambardzumyan A., Hovsepyan A.,Hallet JN.,Sakanyan V. Rational Engineering of the Substrate Specificity of a Thermostable D-Hydantoinase (Dihydropyrimidinase. High-Throughput, 2020, 8, 4. doi:10.3390/ht9010005.


Yaremenko I, Radulov P, Belyakova Y, Demina A, Vilikotskiy A, Barsukov D, Subotina I, Fleury F, Terentev A. Catalyst development for the synthesis of ozonides and tetraoxanes under heterogeneous conditions. Disclosure of an unprecedented class of fungicides for agricultural application. Chem. Eur. J., 2019. doi:10.1002/chem.201904555. Accepté

Velic D, Charlier C, Popova M, Jaunet-Lahary T, Bouchouireb Z, Henry S, Weigel P, Masson JY, Laurent A, Nabiev I, Fleury F. Interactions of the Rad51 inhibitor DIDS with human and bovine serum albumins : Optical spectroscopy and isothermal calorimetry approaches. Biochimie, 2019, 167,187-197. doi : 10.1016/j.biochi.2019.09.016.

Chabot T, Defontaine A, Marquis D, Renodon-Corniere A, Courtois E, Fleury F, Cheraud Y. New Phosphorylation Sites of Rad51 by c-Met Modulates Presynaptic Filament Stability. Cancers (Basel), 2019, 11(3) DOI : 10.3390/cancers11030413.


Benhelli-Mokrani H, Mansuroglu Z, Chauderlier A, Albaud B, Gentien D, Sommer S, Schirmer C, Laqueuvre L, Josse T, Buée L, Lefebvre B, Galas MC, Souès S, Bonnefoy E. Genome-wide identification of genic and intergenic neuronal DNA regions bound by Tau protein under physiological and stress conditions. Nucleic Acids Res., 2018, 46(21):11405-11422. doi:10.1093/nar/gky929

Deriabin KV, Yaremenko IA, Chislov MV, Fleury F, Terentev AO, Islamova RM.  Similar nature leads to improved properties. New J Chem, 2018, 42, 15006-13.

Lafont F., Ayadi N., Charlier C., Weigel P., Nabiev I., Benhelli-Mokrani H., Fleury F. Assessment of DNA-PKcs kinase activity by quantum dot–based microarray. Sci. Rep., 2018, 8(10968) DOI:10.1038/s41598-018-29256-2.

Jaunet-Lahary T., Vercauteren D., Fleury F., Laurent A. Computational Simulations Determining Disulfonic Stilbene Derivatives Biodisponibility Within Human Serum Albumin. Physical Chemistry Chemical Physics, 2018, 4 ;20(26):18020-18030, DOI : 10.1039/c8cp00704g.


Faucon A., Benhelli-Mokrani H., Fleury F., Dutertre S., Tramier M., Boucard J., Lartigue L., Nedellec S., Hulin P., Ishow E. Bioconjugated fluorescent organic nanoparticles targeting EGFR-overexpressing cancer cells. Nanoscale 2017, 9(45):18094-18106. doi : 10.1039/c7nr06533g.

Alligand B., Le Breton M., Marquis D., Vallette F., Fleury F. Functional effects of diphosphomimetic mutations at cAbl-mediated phosphorylation sites on Rad51 recombinase activity. Biochimie 2017, 139:115-124. doi:10.1016/j.biochi.2017.05.020.

Bosseboeuf A, Feron D, Tallet A, Rossi C, Charlier C, Garderet L, Caillot D, Moreau P, Cardó-Vila M, Pasqualini R, Arap W, Nelson AD, Wilson BS, Perreault H, Piver E, Weigel P, Girodon F, Harb J, Bigot-Corbel E, and Hermouet S. Monoclonal IgG in MGUS and multiple myeloma targets infectious pathogens. JCI Insight 2017, 2(19). pii : 95367

Lafont F., Ayadi F., Charlier C., Weigel P., Nabiev I., Benhelli-Mokrani H., Fleury F. DNA-Dependent Protein Kinase Activity Assessed by Quantum Dot–Based Microarray. FEBS J. 2017, 284 : P1.2-017. doi:10.1111/febs.14174

Chabot T., Benhelli-Mokrani H., Fleury F., Chéraud Y.. Effects of RTK family-mediated Rad51 phosphorylation on Homologous Recombination DNA repair pathway. FEBS J. 2017, 284 : P1.2-027. doi:10.1111/febs.14174

Lafont F., Fleury F., Benhelli-Mokrani H.. The O-GlcNAcylation/Phosphorylation balance of DNA-PKcs in response to DNA double-strand breaks. FEBS J. 2017, 284 : P1.2-005. doi:10.1111/febs.14174


Yaremenko YA., Syroeshkin MA., Levitsky DO, Fleury F., Terent’ev AO. Cyclic peroxides as promising anticancer agents : in vitro cytotoxicity study of synthetic ozonides and tetraoxanes on human prostate cancer cell lines. Medicinal Chemistry Research 2016, DOI:10.1007/s00044-016-1736-2 (IF : 1.52).

Faucon A., Benhelli-Mokrani H., Fleury F, Dubreil L., Hulin P., Nedellec S., Doussineau T., Antoine R., Orlando T., Lascialfari A., Fresnais J., Lartigue L., Ishow E. Tuning the architectural integrity of high-performance magneto-fluorescent core-shell nanoassemblies in cancer cells. J Colloid Interface Sci. 2016, 479:139-49 (IF : 3.78).

Oliveira Silva V A., Lafont F, Benhelli-Mokrani H, LeBreton M, Hulin P, Chabot T, Paris F, Sakanyan V, Fleury F. Rapid diminution of the level and activity of DNA-dependent protein kinase in cancer cells after exposure to a reactive nitro-benzoxadiazole compound. Int. J. Mol. Sci. 2016, 17(5). doi : 10.3390/ijms17050703 (IF : 3.26).

Jaunet-Lahary T, Goupille A, Jacquemin D, Fleury F, Graton J, Laurent A A Joint Theoretical and Experimental Study of the Behaviour of the DIDS Inhibitor and Its Derivatives. Chemphyschem. 2016, doi : 10.1002/cphc.201600107 (IF : 3.42).

Terent’ev AO, Pastukhova ZY, Yaremenko IA, Novikov RA, Demchuk DV, Bruk LG, Levitsky DO, Fleury F, Nikishin GI Selective transformation of tricyclic peroxides with pronounced antischistosomal activity into 2-hydroxy-1,5-diketones using iron (II) salts. Tetrahedron 2016, doi : 10.1016/j.tet.2016.04.054 (IF:2.64).

Sakanyan V, Hulin P, De Sousa R, Silva V, Hambardsumyan A, Nedellec S, Tomasoni C, Loge C, Pineau C, Roussakis C, Fleury F, Artaud I Activation of EGFR by small compounds through coupling the generation of hydrogen peroxide to stable dimerization of Cu/Zn SOD1. Sci. Rep. 2016, doi : 10.1038/srep21088 (IF : 5.58).

Zdvizhkov A.T., Terent’ev A.O., Radulov P.S., Novikov R.A., Tafeenko V.A., Chernyshev V.V., Ilovaiskya A.I., Levitsky D.O., Fleury F., Nikishin G.I. Transformation of 2-allyl-1,3-diketones to bicyclic compounds containing 1,2-dioxolane and tetrahydrofuran rings using the I2 / H2O2 system. Tetrahedron Letters 2016, 57:949-952.


Faucon A, Benhelli-Mokrani H, Córdova LA, Brulin B, Heymann D, Hulin P, Nedellec S, Ishow E. Are Fluorescent Organic Nanoparticles Relevant Tools for Tracking Cancer Cells or Macrophages ? Adv Healthc Mater. 2015, 4(17):2727-34.

Velic D, Couturier A, Ferreira TM, Poirier G, Fleury F, Masson JY. DNA damage signaling and repair inhibitors : the long-sought-after Achille’s heel of cancer. Biomolecule . 2015, 5(4):314-59.

Martin-Jézéquel V, Calu G, Candela L, Amzil Z, Jauffrais T, Séchet V, Weigel P. Effects of Organic and Inorganic Nitrogen on the Growth and Production of Domoic Acid by Pseudo-nitzschia multiseries and P. australis (Bacillariophyceae) in Culture. Mar. Drugs 2015, 13(12), 7067-7086.

Bilan R, Fleury F, Nabiev I, Sukhanova A. Quantum Dot surface chemistry and functionalization for cell targeting and Imaging. Bioconjugate Chem. 2015, 26:609-24 (IF 4.58)


Yaremenko IA, Terent’ev AO, Vil’ VA, Novikov RA, Chernyshev VV, Tafeenko VA, Levitisky DO, Fleury F, Nikishin GI. Approach for the preparation of various classes of peroxides based on the reaction of triketones with H2O2 : first examples of ozonide rearrangements. Chem Eur J. 2014, 20:10160‑9 (IF 5.693)

Terent’ev AO, Vil’ VA, Yaremenko IA, Bityukov OV, Levitsky DO, Chernyshev VV, Nikishin GI, Fleury, F. Preparation of a microsized cerium chloride-based catalyst and its application in the Michael addition of β-diketones to vinyl ketones. New J Chem. 2014, 38:1493-1502 (IF 3.159)

Sakanyan V, Angelini M, Le Béchec M, Lecocq MF, Benaiteau F, Rousseau B, Gyulkhandanyan A, Gyulkhandanyan L, Logé C, Reiter E, Roussakis C, Fleury F. Screening and discovery of nitro-benzoxadiazole compounds activating epidermal growth factor receptor (EGFR) in cancer cells. Sci Rep. 2014, 4:3977 (IF 5.078)

Levitsky DO, Dembitsky VM. Anti-breast Cancer Agents Derived from Plants. Nat Prod Bioprospect. 2014, Dec 3.

Le Cigne A, Menil-Philippot V, Fleury F, Takahashi M, Thiriet C. Transient expression of RAD51 in the late G2-phase is required for cell cycle progression in synchronous Physarum cells. Genes Cells. 2014, 19:755‑65 (IF 2.855)

Fornander LH, Renodon-Cornière A, Kuwabara N, Ito K, Tsutsui Y, Shimizu T, Iwasaki H, Nordén B, Takahashi M. Swi5-Sfr1 protein stimulates Rad51-mediated DNA strand exchange reaction through organization of DNA bases in the presynaptic filament. Nucleic Acids Res. 2014, 42:2358‑65 (IF 8.808)

Esnault C, Renodon-Cornière A, Takahashi M, Casse N, Delorme N, Louarn G, Fleury F, Pilard JF, Chenais B. Assessment of DNA binding to human Rad51 protein by using quartz crystal microbalance and atomic force microscopy : effects of ADP and BRC4-28 peptide inhibitor. Chemphyschem. 2014, 15:3753‑60 (IF 3.36)

Normand A, Rivière E, Renodon-Cornière A. Identification and characterization of human Rad51 inhibitors by screening of an existing drug library. Biochem. Pharmacol. 2014, 91, 293–300 (IF 4.65)

Swed A, Cordonnier T, Fleury F, Boury F. Protein encapsulation into PLGA nanoparticles by a novel phase separation method using non-toxic Solvents. J. Nanomed. Nanotechnol, 2014, 5, 6 (FI 5.978).


Terent’ev AO, Yaremenko IA, Vil’ VA, Moiseev IK, Kon’kov SA, Dembitsky VM, Levitsky DO, Nikishin GI. Phosphomolybdic and phosphotungstic acids as efficient catalysts for the synthesis of bridged 1,2,4,5-tetraoxanes from β-diketones and hydrogen peroxide. Org Biomol Chem. 2013, 11:2613‑23 (IF. 3.568)

Prieur X, Dollet L, Takahashi M, Nemani M, Pillot B, Le May C, Mounier C, Takigawa-Imamura H, Zelenika D, Matsuda F, Feve B, Capeau J, Lathrop M, Costet P, Cariou B, Magre J. Thiazolidinediones partially reverse the metabolic disturbances observed in Bscl2/seipin-deficient mice. Diabetologia. 2013, 56:1813‑25 (IF 6.487)

Gyulkhandanyan A, Gyulkhandanyan L, Ghazaryan R, Fleury F, Angelini M, Gyulkhandanyan G, Sakanyan V. Assessment of new cationic porphyrin binding to plasma proteins by planar microarray and spectroscopic methods. J Biomol Struct Dyn. 2013, 31:363‑75 (IF 2.983)

Weigel P, Marc F, Aganyants H-A, Sakanyan V-A. Characterization of Thermostable Hydantoinases Cloned from Geobacillus stearothermophilus. National academy of Sciences of Armenia, Reports in biochemistry, 2013, 1:92-98

Feron D, Charlier C, Gourain V, Garderet L, Coste-Burel M, Le Pape P, Weigel P, Jacques Y, Hermouet S, Bigot-Corbel E. Multiplexed protein microarray immunoassay suitable for the study of the specificity of monoclonal immunoglobulins. Anal Biochem. 2013, 433:202-9 (IF 2.305).


Fornander LH, Frykholm K, Reymer A, Renodon-Cornière A, Takahashi M, Nordén B. Ca2+ improves organization of single-stranded DNA bases in human Rad51 filament, explaining stimulatory effect on gene recombination. Nucleic Acids Res. 2012, 40:4904‑13 (IF 8.278)

Atwell S, Disseau L, Stasiak AZ, Stasiak A, Renodon-Cornière A, Takahashi M, Viovy JL, Cappello G. Probing Rad51-DNA interactions by changing DNA twist. Nucleic Acids Res. 2012, 40:11769‑76 (IF 8.278)


Terent’ev AO, Platonov MM, Levitsky DO, Dembitsky VM. Organosilicon and organogermanium peroxides : synthesis and reactions. Russ Chem Rev. 2011, 80:807‑28 (IF 2.299)

Slupianek A, Dasgupta Y, Ren S-Y, Gurdek E, Donlin M, Nieborowska-Skorska M, Fleury F, Skorski T. Targeting RAD51 phosphotyrosine-315 to prevent unfaithful recombination repair in BCR-ABL1 leukemia. Blood. 2011, 118:1062‑8 (IF 9.06)

Lebedev AV, Pelouch V, Ivanova MV, Levitsky DO. A quantitative evaluation of redox-active compounds in human blood lipids. Hemoglobin. 2011, 35:247‑54 (IF 0.894)

Elenkov I, Pelovsky P, Ugrinova I, Takahashi M, Pasheva E. The DNA Binding and Bending Activities of Truncated Tail-less HMGB1 protein are Differentially Affected by Lys-2 and Lys-81 Residues and Their Acetylation. Int J Biol Sci. 2011, 7:691‑9 (IF 3.168)

Temina M, Levitsky DO, Dembitsky VM. Chemical Constituents of the Epiphytic and Lithophilic Lichens of the Genus Collema. Rec Nat Prod. 2010, 4:79‑86 (IF 1.019)

Takizawa Y, Qing Y, Takaku M, Ishida T, Morozumi Y, Tsujita T, Kogame T, Hirota H, Takahashi M, Shibata T, Kurumizaka H, Takeda S. GEMIN2 promotes accumulation of RAD51 at double-strand breaks in homologous recombination. Nucleic Acids Res. 2010, 38:5059‑74 (IF 8.278)

Rousserie G, Sukhanova A, Even-Desrumeaux K, Fleury F, Chames P, Baty D, Oleinikov V, Cohen JHM, Nabiev I. Semiconductor quantum dots for multiplexed bio-detection on solid-state microarrays. Crit Rev Oncol Hematol. 2010, 74:1‑15 (IF 4.637)

Renaud V, Godefroy E, Larrieu P, Fleury F, Jotereau F, Guilloux Y. Folding of matrix metalloproteinase-2 prevents endogenous generation of MHC class-I restricted epitope. PloS One. 2010, 5:e11894 (IF 3.73)

Nomme J, Renodon-Cornière A, Asanomi Y, Sakaguchi K, Stasiak AZ, Stasiak A, Norden B, Tran,V, Takahashi M. Design of potent inhibitors of human RAD51 recombinase based on BRC motifs of BRCA2 protein : modeling and experimental validation of a chimera peptide. J Med Chem. 2010, 53:5782‑91 (IF 5.614)

Martinez S, Renodon-Cornière A, Nomme J, Eveillard D, Fleury F, Takahashi M, Weigel P. Targeting human Rad51 by specific DNA aptamers induces inhibition of homologous recombination. Biochimie. 2010, 92:1832‑8 (IF 3.142)

Dembitsky VM, Terent’ev AO, Levitsky DO. Amino and Fatty Acids of Wild Edible Mushrooms of the Genus Boletus. Rec Nat Prod. 2010, 4:218‑23 (IF 1.56)