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Publications de l’équipe Ingénierie moléculaire et glycobiologie


Storozhylova N, Crecente-Campo J, Álvarez D C, Lugo L, Dussouy C, Simões S I D, Monteiro M, Grandjean C, Alonso M J. Nanoparticles laden in situ hyaluronic acid-fibrin gel for intra-articular treatment of the inflammatory joint diseases. Reg. Eng. Transl. Med. 2020, accepté

Dussouy C, Kishor C, Lambert A, Lamoureux C, Blanchard H, Grandjean C. Linear triazole-linked pseudo oligogalactosides as scaffolds for galectin inhibitor development. Chem. Biol. Drug. Des. 2020, sous presse

Violo T, Benhada F, Dussouy C, Tellier C, Grandjean C, Camberlein E. Homogenous Glycoconjugate Produced by Combined Non-Canonical Amino Acid Incorporation and Click-Chemistry for Vaccine Purposes J. Visual Exp. 2020, doi:10.3791/60821

Visnapuu T, Teze D, Kjeldsen C, Lie A, Duus J O, André-Miral C, Haastrup L, Pedersen L H, Stougaard P, Svensson B. Identification and characterization of a β-N-acetylhexosaminidase with a biosynthetic activity from the marine bacterium Paraglaciecola hydrolytica S66T. Int. J. Mol. Sci. 21 2020, doi:10.3390/ijms21020417.es

Teze D, Coines J, Raich L, Kalichuk V, Solleux C, Tellier C, André-Miral C, Svensson B, Rovira C. A single point mutation converts GH84 O-GlcNAc hydrolases into phosphorylases. Experimental and theoretical evidence. J. Am. Chem. Soc. 2020, 142, 2120-2124. doi:10.1021/jacs.9b09655


David B, Arnaud P, Tellier C, Sanejouand Y-H. Toward the design of efficient transglycosidases : the case of the GH1 of Thermus thermophilus. Protein Eng Des Sel. 2019, doi : 10.1093/protein/gzz032.

Bogoeva V, Rangelov M, Todorova N, Lambert A, Bridot C, Yordanova A, Roos G, Grandjean C, Bouckaert J. Binding of gold(III) porphyrin by the pro-metastatic regulatory protein human galectin-3. Molecules 24 2019, pii : E4561. doi:10.3390/molecules24244561

Brissonnet Y, Compain G, Renoux B, Daligault F, Deniaud D, Papot S, Gouin S G. Design of multivalent glucuronides with self-immolative linkers and their hydrolysis rate by β-glucuronidase. RSC Advances 9 2019, 40263-40267

Chabot T, Defontaine A, Marquis D, Renodon-Corniere A, Courtois E, Fleury F, Cheraud Y. New Phosphorylation Sites of Rad51 by c-Met Modulates Presynaptic Filament Stability. Cancers 2019, 11, 413

Brinkø A, Risinger C, Lambert A, Blixt O, Grandjean C, Jensen HH. Combining Click Reactions for the One-Pot Synthesis of Modular Biomolecule Mimetics. Org Lett. 2019, 21(18):7544-7548. https://doi.org/10.1021/acs.orglett....

Pillot A, Defontaine A, Fateh A, Lambert A, Prasanna M, Fanuel M, Pipelier M, Csaba N, Violo T, Camberlein E, Grandjean C Site-Specific Conjugation for Fully Controlled Glycoconjugate Vaccine Preparation. Front Chem. 2019, https://doi.org/10.3389/fchem.2019.00726

Prasanna M, Soulard D, Camberlein E, Ruffier N, Lambert A, Trottein F, Csaba N, Grandjean C. Semisynthetic glycoconjugate based on dual role protein/PsaA as a pneumococcal vaccine. Eur J Pharm Sci. 2019, 129, 31-41.

Brissonnet Y, Assailly C, Saumonneau A, Bouckaert J, Maillasson M, Petitot C, Roubinet B, Didak B, Landemarre L, Bridot C, Blossey R, Deniaud D, Yan X, Bernard J, Tellier CGrandjean C, Daligault F, Gouin SG. Multivalent Thiosialosides and Their Synergistic Interaction with Pathogenic Sialidases. Chemistry. 2019, 25(9), 2358-2365.

Naretto A, Fanuel M, Ropartz D, Rogniaux H, Larocque R, Czjzek M, Tellier C, Michel G. The agar-specific hydrolase ZgAgaC from the marine bacterium Zobellia galactanivorans defines a new GH16 protein subfamily. J Biol Chem. 2019, 294(17):6923-6939. https://doi.org/10.1074/jbc.RA118.006609


Alvarez-Dorta D, Brissonnet Y, Saumonneau A, Deniaud D, Bernard J, Yan X, Tellier CDaligault F, Gouin S G. Magnetic Nanoparticles Coated with Thiomannosides or Iminosugars to Switch and Recycle Galactosidase Activity. ChemistrySelect 2017, 2 (29), 9552-9556.

Dion, J, Advedissian T, Storozhylova N, Dahbi S, Lambert A, Deshayes F, Viguier M, Tellier C, Poirier F, Téletchéa S, Dussouy C, Tateno H, Hirabayashi J, Grandjean C. Development of a sensitive microarray platform for the ranking of galectin inhibitors : identification of a selective galectin-3 inhibitor. Chembiochem 2017, 18, 2428-2440.

Legentil, L. ; Cabezas, Y. ;, Tasseau, O. ; Tellier, C. ; Daligault, F. ; Ferrieres, V.. Regioselective galactofuranosylation for the synthesis of disaccharide patterns found in pathogenic microorganisms. J Org Chem. 2017, 82(14), 7114-7122.

Atmanene, C. ; Ronin, C. ; Gautier, F.-M. ; Djedaïni-Pilard, F. ; Télétchéa, S., Ciesielski, F. ; Vivat, V. ; Grandjean, C. Biophysical and structural characterization of mono/di-arylated lactosamine derivatives interaction with human galectin-3. Biochem Biophys Res Commun . 2017, 489, 281-286.

David, B., Irague, R., Jouanneau, D., Daligault, F., Czjzek, M., Sanejouand, Y.-H., & Tellier, C. Internal Water Dynamics Control the Transglycosylation/Hydrolysis Balance in the Agarase (AgaD) of Zobellia galactanivorans. ACS Catalysis 2017, 7:3357–3367. https://doi.org/10.1021/acscatal.7b00348

Dion, J. ; Deshayes, F. ; Storozhylova, N. ; Advedissian, T. ; Lambert, A. ; Viguier, M. ; Tellier, C. ; Dussouy, C. ; Poirier, F. ;* Grandjean, C. Lactosamine-Based Derivatives as Tools to Delineate the Biological Functions of Galectins : Application to Skin Tissue Repair. Chembiochem . 2017, 18(8), 782-789 doi : 10.1002/cbic.201600673.

Coppin L, Vincent A, Frénois F, Duchêne B, Lahdaoui F, Stechly L, Renaud F, Villenet C, Seuningen IV, Leteurtre E, Dion J, Grandjean C, Poirier F, Figeac M, Delacour D, Porchet N, Pigny P. Galectin-3 is a non-classic RNA binding protein that stabilizes the mucin MUC4 mRNA in the cytoplasm of cancer cells. Sci Rep . 2017 Mar 6 ;7:43927. doi : 10.1038/srep43927


Forato F, Liu H, Benoit R, Fayon F, Charlier C, Fateh A, Defontaine A, Tellier C, Talham D R, Queffelec C, Bujoli, Bruno. Comparison of Zirconium Phosphonate-Modified Surfaces for Immobilizing Phosphopeptides and Phosphate-Tagged Proteins. Langmuir : the ACS journal of surfaces and colloids . 2016, 32(22):5480-5490. doi : 10.1021/acs.langmuir.6b01020

Goux M, Fateh A, Defontaine, Cinier M, Tellier C. In vivo phosphorylation of a peptide tag for protein purification. Biotechnol Lett . 2016, doi : 10.1007/s10529-016-2040-4


Saumonneau A, Champion E, Peltier-Pain P, Molnar-Gabor D, Hendrickx J, Tran V, Hederos M, Dekany G, Tellier C. Design of an alpha-L-transfucosidase for the synthesis of fucosylated HMOs. Glycobiology . 2015, doi : 10.1093/glycob/cwv099

Cabezas Y, Legentil L, Robert-Gangneux F, Daligault F, Belaz S, Nugier-Chauvin C, Tranchimand S, Tellier C, Gangneux J-P, Ferrieres V. Leishmania cell wall as a potent target for antiparasitic drugs. A focus on the glycoconjugates. Org Biomol Chem. 2015, 13:8393-8404 (IF 3.568)

Teze D, Daligault F, Ferrières V, Sanejouand Y-H, Tellier C. Semi-rational approach for converting a GH36 α-glycosidase into an α-transglycosidase. Glycobiology. 2015, 25:420‑427 (IF 3.537)

André-Miral C, Koné FM, Solleux C, Grandjean C, Dion M, Tran V, Tellier C. De novo design of a trans-β-N-acetylglucosaminidase activity from a GH1 β-glycosidase by mechanism engineering. Glycobiology. 2015, 25:394-402 (IF 3.537)

Advedissian T, Deshayes F, Poirier F, Grandjean C, Viguier M. Les galectines, des lectines pas comme les autres. Med Sci (Paris). 2015, 31:499-505 (IF 0.519)

Brissonnet Y, Ladevèze S, Tezé D, Fabre E, Deniaud D, Daligault F, Tellier C, Sestak S, Remaud-Simeon M, Potocki-Veronese G, Gouin SG. Polymeric iminosugars improve the activity of carbohydrate-processing enzymes. Bioconjug Chem. 2015, 26:766‑72 (IF 4.58)

Arab-Jaziri F, Bissaro B, Tellier C, Dion M, Fauré R, O’Donohue MJ. Enhancing the chemoenzymatic synthesis of arabinosylated xylo-oligosaccharides by GH51 α-l-arabinofuranosidase. Carbohydr Res. 2015, 401:64‑72 (IF 2.044)


Wade WF, King RG, Grandjean C, Wade T K, Justement LB. Murine marginal zone B cells play a role in Vibrio cholerae LPS antibody responses. Pathog Dis. 2014, 70:153–157 (IF 2.554)

Teze D, Hendrickx J, Czjzek M, Ropartz D, Sanejouand Y-H, Tran V, Tellier C, Dion M.. Semi-rational approach for converting a GH1 β-glycosidase into a β-transglycosidase. Protein Eng Des Sel. 2014, 27:13‑9 (IF 2.588)

Milhomme O, Grandjean C. Synthetic efforts towards glycoconjugate-based vaccines active against Anthrax. Curr Org Chem. 2014, 18:291–311 (IF 3.039)

Suleman M, Gangneux J-P, Legentil L, Belaz S, Cabezas Y, Manuel C, Dureau R, Sergent O, Burel A, Daligault F, Ferrières V, Robert-Gangneux F. Alkyl galactofuranosides strongly interACTwith Leishmania donovani membrane and provide antileishmanial activity. Antimicrob Agents Chemother. 2014, 58:2156-2166 (IF 4.451)

Liu H, Charlier C, Defontaine A, Fateh A, Tellier C, Talham DR, Bujoli B. Design and optimization of a phosphopeptide anchor for specific immobilization of a capture protein on zirconium phosphonate modified supports. Langmuir. 2014, 30:13949‑55 (IF 4.187)


Teze D, Hendrickx J, Dion M, Tellier C, Woods VL, Tran V, Sanejouand Y-H. Conserved water molecules in family 1 glycosidases : a DXMS and molecular dynamics study. Biochemistry. 2013, 52:5900‑10 (IF 3.194)

Teze D, Dion M, Daligault F, Tran V, André-Miral C, Tellier C. Alkoxyamino glycoside acceptors for the regioselective synthesis of oligosaccharides using glycosynthases and transglycosidases. Bioorg Med Chem Lett. 2013, 23:448‑51 (IF 2.338)

Grandjean C, Wade TK, Ropartz D, Ernst L, Wade WF. Acid-detoxified Inaba lipopolysaccharide (pmLPS) is a superior cholera conjugate vaccine immunogen than hydrazine-detoxified lipopolysaccharide and induces vibriocidal and protective antibodies. Pathog Dis. 2013, 67:136‑58 (IF 2.554)

Arab-Jaziri F, Bissaro B, Dion M, Saurel O, Harrison D, Ferreira F, Milon A, Tellier C, Fauré R, O’Donohue MJ. Engineering transglycosidase activity into a GH51 α-l-arabinofuranosidase. New biotechnology. 2013, 30:536‑44 (IF 1.706)


Rigouin C, Delbarre-Ladrat C, Ratiskol J, Sinquin C, Colliec-Jouault S, Dion M. Screening of enzymatic activities for the depolymerisation of the marine bacterial exopolysaccharide HE800. Appl Microbiology Biot. 2012, 96:143‑51 (IF 3.689)

Muse M, Grandjean C, Wade TK, Wade WF. A one dose experimental cholera vaccine. FEMS Immunol Med Mic. 2012, 66:98‑115 (IF 2.684)

Milhomme O, Köhler SM, Ropartz D, Lesur D, Pilard S, Djedaïni-Pilard F, Beyer W, Grandjean C. Synthesis and immunochemical evaluation of a non-methylated disaccharide analogue of the anthrax tetrasaccharide. Org Biomol Chem. 2012, 10:8524–32 (IF 3.568)

Milhomme O, Dhénin SGY, Djedaïni-Pilard F, Moreau V, Grandjean C. Synthetic studies toward the anthrax tetrasaccharide : alternative synthesis of this antigen. Carbohydr Res. 2012, 356:115‑31
(IF 2.044)

Cinier M, Petit M, Pecorari F, Talham DR, Bujoli B, Tellier C. Engineering of a phosphorylatable tag for specific protein binding on zirconium phosphonate based microarrays. J Biol Inorg Chem. 2012, 17:399‑407 (IF 3.253)


Roy B, Ferdjani S, Tellier C, Rabiller C. Novel and convergent synthesis of modified glycosphingolipids, galactosyl-5-aza-sphinganines, by a diversity-oriented method. Tetrahedron. 2011, 67:5176‑83 (IF 2.803)

Miranda FF, Brient-Litzler E, Zidane N, Pecorari F, Bedouelle H. Reagentless fluorescent biosensors from artificial families of antigen binding proteins. Biosens Bioelectron. 2011, 26:4184‑90 (IF 5.437)

Ferdjani S, Ionita M, Roy B, Dion M, Djeghaba Z, Rabiller C, Tellier C. Correlation between thermostability and stability of glycosidases in ionic liquid. Biotechnol lett. 2011, 33:1215‑9 (IF 1.853)

Charrier T, Durand MJ, Jouanneau S, Dion M, Pernetti M, Poncelet D, Thouand G. A multi-channel bioluminescent bacterial biosensor for the on-line detection of metals and toxicity. Part I : design and optimization of bioluminescent bacterial strains. Anal Bioanal Chem. 2011, 400:1051-60 (IF 3.659)

Béhar G, Solé V, Defontaine A, Maillasson M, Quéméner A, Jacques Y, Tellier C. Evolution of interleukin-15 for higher E. coli expression and solubility. Protein Eng Des Sel. 2011, 24:283‑90 (IF 2.588)


Tran V, Hoffmann L, Rabiller C, Tellier C, Dion M. Rational design of a GH1 β-glycosidase to prevent self-condensation during the transglycosylation reaction. Protein Eng Des Sel. 2010, 23:43‑9 (IF 2.588)

Rahuel-Clermont S, Daligault F, Piet M-H, Gulberti S, Netter P, Branlant G, Magdalou J, Lattard V. Biochemical and thermodynamic characterization of mutated β1, 4- galactosyltransferase 7 involved in the progeroid form of the Ehlers- Danlos syndrome. Biochem J. 2010, 432:303-311 (IF 4.654)

Hajj HE, Abdelouas A, Grambow B, Martin C, Dion M. Microbial corrosion of P235GH steel under geological conditions. Phys Chem Earth. 2010, 35:248‑53 (IF 1.037)